Facile chelation-controlled reductive opening of methoxybenzylidene acetals with Bu3SnH and MgBr2.: Regioselective protection strategy as MPM ethers

被引：53

作者：

Zheng, BZ ^{[1
]}

Yamauchi, M ^{[1
]}

Dei, H ^{[1
]}

Kusaka, S ^{[1
]}

Matsui, K ^{[1
]}

Yonemitsu, O ^{[1
]}

机构：

[1] Okayama Univ Sci, Fac Sci, Dept Chem, Okayama 7000005, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 33期

关键词：

protecting group; benzylidene acetal; reductive cleavage; chelation; regioselection; tri-n-butyltin hydride; magnesium bromide;

D O I：

10.1016/S0040-4039(00)01017-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient regioselective reductive opening of methoxybenzylidene acetals using a combination of Bu3SnH and MgBr2. OEt2, mainly via five-membered chelation intermediates is described. This reaction was applied to synthetic intermediates of myriaporon and tedanolide. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：6441 / 6445

页数：5