Scientific Basis for the First-in-Human Trial of "Neo-Islet"-Mediated Functional Cure of T1DM: The Intraperitoneal Administration of "Neo-Islets," 3-D Organoids of Allogeneic Islet and Mesenchymal Stromal Cells from Rodents, Dogs, and Humans Durably Cures

被引：0

作者：

Westenfelder, Christof

Chowdhury, Sabiha S.

Gooch, Anna

机构：

来源：

DIABETES | 2022年 / 71卷

关键词：

D O I：

10.2337/db22-841-P

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

841-P

引用

页数：1

共 7 条

[1] Effective and Durable Stem-Cell-Enabled Therapy of Autoimmune T1DM in Rodents and Dogs Provides the Scientific Basis for the First-in-Human Trial Using I. P. Administered "Neo-Islets," 3-D Organoids of Allogeneic Islet, and Mesenchymal Stromal Cells-The Omentum Becomes the New Endocrine Pancreas without the Need for Antirejection Drugs
Gooch, Anna
Westenfelder, Christof
DIABETES, 2023, 72
[2] INAD 012-776 Pilot Study: Allogeneic "Neo-Islets," Composed of Mesenchymal Stem and Islet Cells, Are Immune Protected and Dose-Dependently and Durably Control Autoimmune T1DM in Pet Dogs
Westenfelder, Christof
Chowdhury, Sabiha S.
Gooch, Anna
DIABETES, 2019, 68
[3] Intraperitoneal administration of human "Neo-Islets", 3-D organoids of mesenchymal stromal and pancreatic islet cells, normalizes blood glucose levels in streptozotocin-diabetic NOD/SCID mice: Significance for clinical trials
Westenfelder, Christof
Hu, Zhuma
Zhang, Ping
Gooch, Anna
PLOS ONE, 2021, 16 (10):
[4] Redosing of Suboptimally Controlled Diabetic Mice with Human Neo-islets, 3D Aggregates of Mesenchymal Stromal and Pancreatic Islet Cells, Durably Restores Euglycemia: Relevance to the Treatment of Diabetic Humans
Chowdhury, Sabiha S.
Gooch, Anna
Zhang, Ping
Hu, Zhuma
Westenfelder, Christof
DIABETES, 2020, 69
[5] Significant expansion of the donor pool achieved by utilizing islets of variable quality in the production of allogeneic "Neo-Islets", 3-D organoids of Mesenchymal Stromal and islet cells, a novel immune-isolating biotherapy for Type I Diabetes
Gooch, Anna M.
Chowdhury, Sabiha S.
Zhang, Ping M.
Hu, Zhuma M.
Westenfelder, Christof
PLOS ONE, 2023, 18 (08):
[6] The Mesenchymal Stromal Cells in "Neo-islets," IsletSized 3D Organoids Composed of MSCs and Islet Cells That Functionally Cure Type 1 Diabetes, Actively Preserve Normal ATP Levels and Viability of ICs In Vitro and In Vivo-Applicable to Islet and iPSC-Derived Therapies of Type 1 Diabetes Mellitus
Gooch, Anna
Westenfelder, Christof
DIABETES, 2024, 73
[7] Allogeneic "Neo-lslets," Organoids Composed of Cultured Pancreatic Islet and Mesenchymal Stromal Cells from Diverse Donors, Afford a Marked Increase in the Global Availability of a Curative, Novel, Anti-Rejection-Drug-Independent Biotherapy of T1DM
Westenfelder, Christof
Chowdhury, Sabiha S.
Gooch, Anna
DIABETES, 2021, 70

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