Host gene-microbiome interactions: molecular mechanisms in inflammatory bowel disease

被引：9
|
作者：
Chu, Hiutung [1 ]
机构：
[1] CALTECH, Pasadena, CA 91125 USA
来源：
GENOME MEDICINE | 2017年 / 9卷
关键词：
GUT MICROBIOME; PATHOGENESIS;
D O I：
10.1186/s13073-017-0459-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent studies have identified links between host genetic variants and microbial recognition of the microbiome. Defects in host-microbiome interactions in individuals harboring inflammatory bowel disease risk alleles may result in imbalances of the microbial community, impaired pathogen clearance, and failure to sense beneficial commensal microbes. These findings highlight the importance of maintaining bi-directional communication at the mucosal interface during intestinal homeostasis.
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页数：3
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