A Mild and Base-Free Protocol for the Ruthenium-Catalyzed Hydrogenation of Aliphatic and Aromatic Nitriles with Tridentate Phosphine Ligands

被引：31
|
作者：
Adam, Rosa [1 ]
Bheeter, Charles Beromeo [1 ]
Jackstell, Ralf [1 ]
Beller, Matthias [1 ]
机构：
[1] Leibniz Inst Katalyse eV, Albert Einstein Str 29A, D-18059 Rostock, Germany
来源：
CHEMCATCHEM | 2016年 / 8卷 / 07期
关键词：
amines; hydrogenation; nitriles; phosphine ligands; ruthenium; CARBOXYLIC-ACID ESTERS; PRIMARY AMINES; SELECTIVE HYDROGENATION; REDUCTIVE AMINATION; CARBON-DIOXIDE; N-ALKYLATION; FORMIC-ACID; METHYLATION; ALCOHOLS; AMIDES;
D O I：
10.1002/cctc.201501367
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
A novel protocol for the general hydrogenation of nitriles in the absence of basic additives is described. The system is based on the combination of [Ru(cod)(methylallyl)(2)] (cod=cyclooctadiene) and L2. A variety of aromatic and aliphatic nitriles is hydrogenated under mild conditions (50 degrees C and 15bar H-2) with this system. Kinetic studies revealed higher activity in the case of aromatic nitriles compared with aliphatic ones.
引用
收藏
页码：1329 / 1334
页数：6
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