High performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP stationary phase

被引：3
|
作者：
Wang, Yan [1 ,2 ]
Yao, Qing Qiang [3 ]
Wang, Mu Zou [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Shandong Acad Med Sci, Inst Mat Med, Jinan 250062, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 07期
关键词：
Enantiomers; (-)Clausenamide; (+)Clausenamide; Chiral-AGP; HPLC;
D O I：
10.1016/j.cclet.2010.01.024
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A method of high performance liquid chromatographic separation of clausenamide enantiomers with chiral-AGP (alpha(1)-acid glycoprotein) stationary phases has been established. The absolute configurations of ()clausenamide and (+)clausenamide are 3S, 4R, 5R, 65 and 3R, 4S, 5S, 6R, respectively. The present method has been used to analyze the ()clausenamide and (+)clausenamide and its analogues such as the major metabolite and synthetic derivatives of clausenamide. (C) 2010 Yan Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
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页码：860 / 863
页数：4
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