Racemization studies of Fmoc-Cys-(Trt)-OH during stepwise Fmoc-solid phase peptide synthesis

被引：45
|
作者：
Kaiser, T
Nicholson, GJ
Kohlbau, HJ
Voelter, W
机构：
[1] UNIV TUBINGEN,INST PHYSIOL CHEM,PHYS BIOCHEM ABT,D-72076 TUBINGEN,GERMANY
[2] UNIV TUBINGEN,INST ORGAN CHEM,D-72076 TUBINGEN,GERMANY
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 08期
关键词：
D O I：
10.1016/0040-4039(95)02406-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In conventional stepwise Fmoc solid phase peptide synthesis, diisopropylethylamine (DIEA) base-catalyzed acylation methods lead to considerable amounts of racemization of Fmoc-Cys(Trt) residues during the activation/coupling process. The epimerization can be reduced to a negligible degree, via. a base-free activation step.
引用
收藏
页码：1187 / 1190
页数：4
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