Controlled drug delivery systems: Past forward and future back

被引:438
|
作者
Park, Kinam [1 ]
机构
[1] Purdue Univ, Dept Biomed Engn & Pharmaceut, W Lafayette, IN 47907 USA
关键词
Evolution of drug delivery; Smart polymers; Modulated delivery; Targeted delivery; Depot formulations; BLOCK-COPOLYMER MICELLES; IN-VIVO; TRANSFECTION EFFICIENCY; CANCER-CHEMOTHERAPY; RELEASE; NANOPARTICLES; CARRIERS; CHITOSAN; BIODISTRIBUTION; LIPOSOMES;
D O I
10.1016/j.jconrel.2014.03.054
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Controlled drug delivery technology has progressed over the last six decades. This progression began in 1952 with the introduction of the first sustained release formulation. The 1st generation of drug delivery (1950-1980) focused on developing oral and transdermal sustained release systems and establishing controlled drug release mechanisms. The 2nd generation (1980-2010) was dedicated to the development of zero-order release systems, self-regulated drug delivery systems, long-term depot formulations, and nanotechnology-based delivery systems. The latter part of the 2nd generation was largely focused on studying nanoparticle formulations. The Journal of Controlled Release (JCR) has played a pivotal role in the 2nd generation of drug delivery technologies, and it will continue playing a leading role in the next generation. The best path towards a productive 3rd generation of drug delivery technology requires an honest, open dialog without any preconceived ideas of the past. The drug delivery field needs to take a bold approach to designing future drug delivery formulations primarily based on today's necessities, to produce the necessary innovations. The JCR provides a forum for sharing the new ideas that will shape the 3rd generation of drug delivery technology. (C) 2014 Elsevier B. V. All rights reserved.
引用
收藏
页码:3 / 8
页数:6
相关论文
共 50 条
  • [1] Controlled drug delivery systems: Past forward and future back
    [J]. Park, K. (kpark@purdue.edu), 1600, Elsevier B.V., Netherlands (190):
  • [2] Back to the Future or Forward to the Past?
    Kuna, Samuel T.
    [J]. SLEEP, 2011, 34 (11) : 1455 - 1456
  • [3] BACK TO THE FUTURE - OR FORWARD TO THE PAST
    DEDOMBAL, FT
    [J]. GUT, 1987, 28 (04) : 373 - 376
  • [4] Drug delivery systems: Past, present, and future
    Mainardes, RM
    Silva, LP
    [J]. CURRENT DRUG TARGETS, 2004, 5 (05) : 449 - 455
  • [5] Past, Present, and Future Drug Delivery Systems for Antiretrovirals
    Kirtane, Ameya R.
    Langer, Robert
    Traverso, Giovanni
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 105 (12) : 3471 - 3482
  • [6] Past and future evolution in colloidal drug delivery systems
    Boyd, Ben J.
    [J]. EXPERT OPINION ON DRUG DELIVERY, 2008, 5 (01) : 69 - 85
  • [7] Taiwan Issue - Back to the future or forward to the past
    Pereira Pinto, Paulo Antonio
    [J]. MERIDIANO 47-JOURNAL OF GLOBAL STUDIES, 2005, 6 (57) : 6 - 7
  • [8] ISCHEMIA trial: Back to the future or forward to the past?
    Pardo Sanz, Ana
    Marcos Alberca, Pedro
    Luis Zamorano, Jose
    [J]. CARDIOLOGY JOURNAL, 2020, 27 (04) : 342 - 344
  • [9] Radical associationism: Back to the future, or fast forward to the past?
    Dolega, Krzysztof
    Destrebecqz, Arnaud
    Cleeremans, Axel
    [J]. ANNEE PSYCHOLOGIQUE, 2024, 124 (02):
  • [10] DESIGN OF ORAL-DRUG DELIVERY SYSTEMS - PAST, PRESENT AND FUTURE
    HIGUCHI, WI
    HO, NFH
    MERKLE, HP
    [J]. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1983, 9 (07) : 1227 - 1239