The Nodes of Ranvier: Molecular Assembly and Maintenance

被引：119
|
作者：
Rasband, Matthew N. [1 ]
Peles, Elior [2 ]
机构：
[1] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
[2] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel
来源：
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2016年 / 8卷 / 03期
基金：
美国国家卫生研究院; 以色列科学基金会;
关键词：
AXON INITIAL SEGMENTS; PERIPHERAL NERVOUS-SYSTEM; SCHWANN-CELL-MEMBRANE; ACTION-POTENTIAL INITIATION; BETA-IV-SPECTRIN; MYELINATED AXONS; SODIUM-CHANNELS; POTASSIUM CHANNELS; EXTRACELLULAR-MATRIX; PARANODAL JUNCTION;
D O I：
10.1101/cshperspect.a020495
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Action potential (AP) propagation in myelinated nerves requires clustered voltage gated sodium and potassium channels. These channels must be specifically localized to nodes of Ranvier where the AP is regenerated. Several mechanisms have evolved to facilitate and ensure the correct assembly and stabilization of these essential axonal domains. This review highlights the current understanding of the axon intrinsic and glial extrinsic mechanisms that control the formation and maintenance of the nodes of Ranvier in both the peripheral nervous system (PNS) and central nervous system (CNS).
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页数：15
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