Oxy-coal combustion with circulating fluidized bed (OCFB) is a promising technology for CO2 capture and sequestration. However, its development is highly hindered by the high price of electricity and CO2 capture. In this work, a comprehensive life-cycle environmental and economic assessment of OCFB power plants with a pressurized combustor (POCFB) and a supercritical CO2 Brayton cycle is conducted using a specific life-cycle assessment (LCA) method. There are four processes evaluated in this work, including construction material production, transport, raw material mining, and power plant operation. Both environmental midpoint and endpoint impacts are derived and compared. The results show that compared to the oxy-coal combustion power plant, systems with a pressurized combustor and a S-CO2 Brayton cycle have less damage (6-12%) to the human health and the environment. Meanwhile, compared to the OCFB power plant, POCFB has relatively lower costs of electricity, CO2 capture, and CO2 avoidance, which are 58.1 USD/MWh, 15.5 USD/t, and 33.4 USD/t, respectively. The results from the Analytic Hierarchy Process-Technique for Order Preference by Similarity to Ideal Solution methodology show that comprehensively considering the economy, resource, and environment, the POCFB power plant is the best option among the cases from the perspective of residents and the government. The influence of several parameters including net electricity efficiency, CO2 capture rate, boiler investment, coal price, and CO2 tax on the economic indicators is also discussed.