Efficacy of Intratympanic Gentamicin in Meniere's Disease With and Without Migraine

Objective: To compare the efficacy of intratympanic gentamicin injection (ITG) on vertigo control, drop attacks, and functional level in Meniere's disease patients with and without a history of migraine. Patients: Meniere's disease patients (patients with migraine and age-and sex-matched control patients without migraine) treated from 2002 to 2012 who failed medical management and received ITG, with a minimum 2-year follow up. Intervention: ITG. Main Outcome Measures: Vertigo control, drop attack prevalence, and change in functional level. Results: Twenty-eight Meniere's disease patients were included in this study (14 with migraine and 14 matched patients without migraine). There were three men and 11 women in each groups, with a mean age of 53 +/- 8.9 years. Baseline characteristics (Meniere's stage, vertigo frequency, drop attack prevalence, and functional level) before ITG were not significantly different between the two groups. Two patients and 78% of Meniere's disease without migraine patients had class A, B, or C vertigo control (p > 0.999). Change in prevalence of drop attacks (43-7% versus 50-0%, respectively) was also similar (p > 0.999). However, significantly fewer vertigo control class A, B, and C migraine patients achieved functional level 1 or 2 (40%) compared with non-migraine patients (91%) (p = 0.007). Conclusions: Although ITG appears equally effective in treating vertigo and drop attacks in Meniere's disease with and without migraine, patients with migraine derive significantly less benefit in terms of functional improvement.