Synthesis anticancer, antitubercular and antimicrobial activity of some new pyrimidine derivatives

The required compounds 1-aryl-3-(3'-bromophenyl)-2-propen-1-ones (1a-j) were prepared by condensing 3-bromobenzaldehyde with different aryl methyl ketones, which in turn on treated with guanidine hydrochloride, yielded 2-amino-4-(3'-bromophenyl)-6-aryl-pyrimidines (2a-j). The synthesis of 1,6-dihydro-2-mercapto-4-aryl-6-(3'-bromophenyl)-pyrimidines (3a-j) has been carried out by the cyclization of compounds (1a-j) with thiourea in presence of alcoholic KOH, while compounds 5-a-(3'-bromostyryl)-4-benzylidene -1,3-dihydro-pyrimidine-2,4,6-triones (4a-j) have been prepared by condensing 1-aryl-3-(3'-bromophenyl)-2-propene-1-ones (1a-j) with barbituric acid in acetic acid. All the synthesized compounds have been screened-for their antitubercular and antimicrobial activities. Some selected compounds have been selected for their primary anticancer screening.