Dual-tracer approach vs. dual time-point approach in leukocyte scintigraphy in treatment evaluation of persistent chronic prosthetic joint infection

被引：4

作者：

Teiler, Johan ^{[1
,2
]}

Akerlund, Borje ^{[3
,4
]}

Brismar, Harald ^{[1
,5
]}

Savitcheva, Irina ^{[6
]}

Ahl, Marcus ^{[3
,4
]}

Bjareback, Annie ^{[6
]}

Hedlund, Hakan ^{[1
,7
]}

Holstensson, Maria ^{[1
,6
]}

Axelsson, Rimma ^{[1
,6
]}

机构：

[1] Karolinska Inst, Dept Clin Sci Tech & Intervent CLINTEC, SE-17177 Stockholm, Sweden

[2] Karolinska Univ Hosp Huddinge, Dept Radiol, Huddinge, Sweden

[3] Karolinska Inst, Dept Med, Stockholm, Sweden

[4] Karolinska Univ Hosp Huddinge, Unit Infect Dis, Huddinge, Sweden

[5] Karolinska Univ Hosp Huddinge, Dept Orthopaed Surg, Huddinge, Sweden

[6] Karolinska Univ Hosp Huddinge, Funct Med Radiat Phys & Nucl Med, Huddinge, Sweden

[7] Visby Gen Hosp, Dept Orthopaed Surg, Stockholm, Sweden

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 2021年 / 42卷 / 07期

关键词：

biofilm; chronic infection; leukocyte scintigraphy; nuclear medicine; prosthetic joint infection; single-photon emission computed tomography; Tc-99m-HMPAO-white blood cell; treatment evaluation; BONE-MARROW SCINTIGRAPHY; BLOOD-CELL SCINTIGRAPHY; IMAGE ACQUISITION; INTERPRETATION CRITERIA; TOTAL-HIP; ARTHROPLASTY; SPECT/CT; SCANS;

D O I：

10.1097/MNM.0000000000001403

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Background Both dual time-point Tc-99m-hexamethylpropylene amine oxime (HMPAO)-leukocyte scintigraphy and dual-tracer Tc-99m-HMPAO-leukocyte scintigraphy (with the addition of Tc-99m-nanocolloid bone marrow scintigraphy) have been used to diagnose prosthetic joint infection (PJI). A treatment evaluation of persistent PJI using these imaging protocols has yet to be presented. Objective The purpose of this study was to compare the accuracy of dual time-point Tc-99m-HMPAO-leukocyte scintigraphy to the dual-tracer alternative of single time-point Tc-99m-HMPAO-leukocyte scintigraphy or single-photon emission computed tomography/computed tomography (SPECT/CT) combined with a Tc-99m-nanocolloid bone marrow scintigraphy or SPECT/CT, for treatment evaluation of PJI. Material and methods Thirty-one PJI patients under antibiotic treatment were included in this retrospective study. Examinations were organized into three settings. Setting one used dual time-point approach with delayed (2 h) and late (24 h) planar Tc-99m-HMPAO-leukocyte scintigraphy, including both visual and semiquantitative analysis. Setting two used delayed (2 h) planar Tc-99m-HMPAO-leukocyte scintigraphy combined with Tc-99m-nanocolloid bone marrow scintigraphy and for setting three SPECT/CT replaced planar imaging. Results Accuracy was 0.68 for visual evaluation and 0.55 for semiquantitative evaluation of setting one; 0.71 for setting two; and 0.68 for setting three. Sensitivity was 0.54 for visual evaluation and 0.31 for semiquantitative evaluation of setting one; 0.38 for setting two; and 0.46 for setting three. Specificity was 0.78 for visual evaluation and 0.72 for semiquantitative evaluation of setting one; 0.94 for setting two; and 0.83 for setting three. Conclusion No significant difference in accuracy, sensitivity, or specificity between the approaches for treatment evaluation of suspected persistent PJI in the hip or knee was observed. Copyright (C) 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

引用

页码：719 / 724

页数：6

共 1 条

[1] Differentiating suspected nasopharyngeal infection from carcinoma using dual-tracer and multiple time-point technetium-99m sestamibi and white blood cell SPECT/CT imaging
Tan, Andrew Eik Hock
Thang, Sue Ping
Padhy, Ajit Kumar
NUCLEAR MEDICINE COMMUNICATIONS, 2011, 32 (05) : 416 - 418

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