Neuroimmunity: Physiology and Pathology

被引:144
|
作者
Talbot, Sebastien [1 ,2 ]
Foster, Simmie L. [1 ,2 ]
Woolf, Clifford J. [1 ,2 ]
机构
[1] Boston Childrens Hosp, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
来源
关键词
inflammation; nociceptor; pain; immunity; allergy; asthma; pathogen; TRPV1; NaV1.8; NERVE GROWTH-FACTOR; GENE-RELATED PEPTIDE; INFLAMMATORY PAIN HYPERSENSITIVITY; ALLERGIC AIRWAY INFLAMMATION; PRIMARY SENSORY NEURONS; TUMOR-NECROSIS-FACTOR; ION-CHANNEL TRPV1; SUBSTANCE-P; IN-VIVO; NEUROGENIC INFLAMMATION;
D O I
10.1146/annurev-immunol-041015-055340
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Evolution has yielded multiple complex and complementary mechanisms to detect environmental danger and protect tissues from damage. The nervous system rapidly processes information and coordinates complex defense behaviors, and the immune system eliminates diverse threats by virtue of mobile, specialized cell populations. The two systems are tightly integrated, cooperating in local and systemic reflexes that restore homeostasis in response to tissue injury and infection. They further share a broad common language of cytokines, growth factors, and neuropeptides that enables bidirectional communication. However, this reciprocal cross talk permits amplification of maladaptive feedforward inflammatory loops that contribute to the development of allergy, autoimmunity, itch, and pain. Appreciating the immune and nervous systems as a holistic, coordinated defense system provides both new insights into inflammation and exciting opportunities for managing acute and chronic inflammatory diseases.
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页码:421 / 447
页数:27
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