Weight Gain After Orthotopic Liver Transplantation: Is Nonalcoholic Fatty Liver Disease Cirrhosis a Risk Factor for Greater Weight Gain?
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作者:
Kouz, Jasmine
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McGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, CanadaMcGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, Canada
Kouz, Jasmine
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Vincent, Catherine
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Univ Montreal, Dept Med, Div Hepatol, St Luc Hosp,Hosp Ctr, Montreal, PQ H3C 3J7, CanadaMcGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, Canada
Vincent, Catherine
[2
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Leong, Aaron
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McGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, CanadaMcGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, Canada
Leong, Aaron
[1
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Dorais, Marc
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StatSciences Inc, Notre Dame Ille Perrot, PQ, CanadaMcGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, Canada
Dorais, Marc
[3
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Raekel, Agnes
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Univ Montreal, Ctr Hosp, Div Endocrinol, Dept Med,St Luc Hosp, Montreal, PQ H2X 3J4, CanadaMcGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, Canada
Raekel, Agnes
[4
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机构:
[1] McGill Univ, Royal Victoria Hosp, Dept Med, Div Endocrinol,Hosp Ctr, Montreal, PQ H3A 1A1, Canada
[2] Univ Montreal, Dept Med, Div Hepatol, St Luc Hosp,Hosp Ctr, Montreal, PQ H3C 3J7, Canada
[3] StatSciences Inc, Notre Dame Ille Perrot, PQ, Canada
Posttransplant weight gain is common after orthotopic liver transplantation. We sought to determine the extent of weight gain at 5 years after transplantation in patients with nonalcoholic fatty liver disease (NAFLD) cirrhosis versus patients with other types of cirrhosis (non-NAFLD). We studied 126 liver transplants performed between 2005 and 2007 at Saint Luc Hospital, University of Montreal. Seventeen of the 126 patients (13.5%) had NAFLD cirrhosis. Ascites volume was difficult to assess, so we used the body mass index (BMI) at 3 months as the reference BMI. All patients gained weight after transplantation, but BMI increased significantly more and earlier among the NAFLD patients [4.8 versus 1.5 kg/m(2) at 1 year (P = 0.001), 5.0 versus 2.3 kg/m(2) at 2 years (P = 0.01), and 5.6 versus 2.6 kg/m(2) at 5 years (P = 0.009)] in comparison with non-NAFLD patients in unadjusted analyses. The greatest BMI increase over time was investigated with univariate and multivariate logistic regression analyses. The BMI increase was divided into tertiles for each period of time observed. The greatest BMI increase over time was defined as the top tertile of BMI increase. After adjustments for potential confounders (ie, total cholesterol, diabetes, and length of hospital stay), NAFLD was no longer associated with a risk of a greater BMI increase [odds ratio (OR) = 3.73 at 1 year (P = 0.11), OR = 2.15 at 2 years (P = 0.34), and OR = 2.87 at 5 years (P = 0.30)]. These findings suggest the need for multidisciplinary, early, and close weight monitoring for all patients. All patients could benefit from pretransplant counseling regarding weight gain and its consequences. (C) 2014 AASLD.
机构:
Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Siddiqui, Mohammad Bilal
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Patel, Samarth
Faridnia, Masoud
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Virginia Commonwealth Univ, Intemal Med, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Faridnia, Masoud
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Albhaisi, Somaya
Clinton, Joseph
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Virginia Commonwealth Univ, Intemal Med, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Clinton, Joseph
Laurenzano, John
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Virginia Commonwealth Univ, Intemal Med, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Laurenzano, John
Laurenzano, John
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Virginia Commonwealth Univ, Intemal Med, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Laurenzano, John
John, Binu
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Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
John, Binu
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Lee, Hannah
Patel, Vaishali B.
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Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Patel, Vaishali B.
Sterling, Richard K.
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Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Sterling, Richard K.
Stravitz, R. Todd
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Virginia Commonwealth Univ, Gastroenterol Hepatol & Nutr, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Stravitz, R. Todd
Sanyal, Arun J.
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Virginia Commonwealth Univ, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Sanyal, Arun J.
Matherlyi, Scott C.
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Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Matherlyi, Scott C.
Luketic, Velimir A.
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Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
Luketic, Velimir A.
Siddiqui, Mohammad Shadab
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Virginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USAVirginia Commonwealth Univ, Gastroenterol & Hepatol, Richmond, VA 23284 USA
机构:
Seoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
Cho, Eun Ju
Yu, Su Jong
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Seoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
Yu, Su Jong
Jung, Gu Cheol
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Seoul Natl Univ Hosp, Hlthcare Syst Gangnam Ctr, Hlthcare Res Inst, Seoul, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
Jung, Gu Cheol
Kwak, Min-Sun
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Seoul Natl Univ, Hosp Healthcare Syst Gangnam Ctr, Dept Internal Med, 39FL Gangnam Finance Ctr 737, Seoul 135984, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
Kwak, Min-Sun
Yang, Jong In
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Seoul Natl Univ, Hosp Healthcare Syst Gangnam Ctr, Dept Internal Med, 39FL Gangnam Finance Ctr 737, Seoul 135984, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
Yang, Jong In
Yim, Jeong Yoon
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Seoul Natl Univ, Hosp Healthcare Syst Gangnam Ctr, Dept Internal Med, 39FL Gangnam Finance Ctr 737, Seoul 135984, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea
Yim, Jeong Yoon
Chung, Goh Eun
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Seoul Natl Univ, Hosp Healthcare Syst Gangnam Ctr, Dept Internal Med, 39FL Gangnam Finance Ctr 737, Seoul 135984, South KoreaSeoul Natl Univ, Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea