Cell therapy for central nervous system disorders: Current obstacles to progress

被引：50

作者：

Yasuhara, Takao ^{[1
]}

Kawauchi, Satoshi ^{[1
]}

Kin, Kyohei ^{[1
]}

Morimoto, Jun ^{[1
]}

Kameda, Masahiro ^{[1
]}

Sasaki, Tatsuya ^{[1
]}

Bonsack, Brooke ^{[2
]}

Kingsbury, Chase ^{[2
]}

Tajiri, Naoki ^{[3
,4
]}

Borlongan, Cesario V. ^{[2
]}

Date, Isao ^{[1
]}

机构：

[1] Okayama Univ, Dept Neurol Surg, Grad Sch Med, Okayama, Japan

[2] Univ S Florida, Ctr Excellence Aging & Brain Repair, Dept Neurosurg & Brain Repair, Tampa, FL USA

[3] Nagoya City Univ, Grad Sch Med Sci, Dept Neurophysiol & Brain Sci, Nagoya, Aichi, Japan

[4] Nagoya City Univ, Med Sch, Dept Neurophysiol & Brain Sci, Nagoya, Aichi, Japan

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2020年 / 26卷 / 06期

关键词：

cell therapy; iPS cells; Parkinson's disease; stroke; traumatic brain injury; TRAUMATIC BRAIN-INJURY; MESENCHYMAL STEM-CELLS; DOPAMINE NEURONS; PARKINSONS-DISEASE; ISCHEMIC-STROKE; GENE-THERAPY; RAT MODEL; TRANSPLANTATION; TRIALS; NEUROINFLAMMATION;

D O I：

10.1111/cns.13247

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cell therapy for disorders of the central nervous system has progressed to a new level of clinical application. Various clinical studies are underway for Parkinson's disease, stroke, traumatic brain injury, and various other neurological diseases. Recent biotechnological developments in cell therapy have taken advantage of the technology of induced pluripotent stem (iPS) cells. The advent of iPS cells has provided a robust stem cell donor source for neurorestoration via transplantation. Additionally, iPS cells have served as a platform for the discovery of therapeutics drugs, allowing breakthroughs in our understanding of the pathology and treatment of neurological diseases. Despite these recent advances in iPS, adult tissue-derived mesenchymal stem cells remain the widely used donor for cell transplantation. Mesenchymal stem cells are easily isolated and amplified toward the cells' unique trophic factor-secretion property. In this review article, the milestone achievements of cell therapy for central nervous system disorders, with equal consideration on the present translational obstacles for clinic application, are described.

引用

页码：595 / 602

页数：8

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