The effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acids on Δ4-desaturation in HepG2 cells

被引：1
|
作者：
Slomma, N [1 ]
Becker, K [1 ]
Eder, K [1 ]
机构：
[1] Univ Halle Wittenberg, Inst Nutr Sci, D-06108 Halle Saale, Germany
来源：
INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH | 2004年 / 74卷 / 04期
关键词：
HepG2; cells; conjugated linoleic acid; Delta; 4-desaturation; arachidonic acid; eicosapentaenoic acid;
D O I：
10.1024/0300-9831.74.4.243
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The objective of this study was to determine the effects of cis-9, trans-11 and trans-10, cis-12 CLA on the Delta4-desaturation process in HepG2 cells. Experiments were conducted in which HepG2 cells were incubated with 25 mumol/L of those fatty acids and the concentrations of (n-6) and (n-3) polyunsaturated fatty acids in phosphatidyl choline and phosphatidyl ethanolamine were determined. In the presence of eicosapentaenoic acid, cells treated with trans-10, cis-12 CLA had a lower ratio of docosahexaenoic acid [22:6 (n-3)], the product of Delta4-desaturation, to docosapentaenoic acid [22:5 (n-3)], the substrate of Delta4-desaturation in both phospholipids, than control cells or cells treated with cis-9, trans-11 CLA (p < 0.05). This suggests that trans-10, cis-12 CLA Suppresses the Delta4-desaturation process in HepG2 cells.
引用
收藏
页码：243 / 246
页数：4
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