Leber's hereditary optic neuropathy mutations in ethambutol-induced optic neuropathy

被引：13
|
作者：
Hwang, JM
Kim, J
Park, SS
机构：
[1] Seoul Natl Univ, Seoul Municipal Boramae Hosp, Coll Med, Dept Ophthalmol, Seoul 156707, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Clin Pathol, Seoul 151, South Korea
来源：
JOURNAL OF NEUROLOGY | 2003年 / 250卷 / 01期
关键词：
Leber's hereditary optic neuropathy; mitochondrial DNA mutation; toxic optic neuropathy; ethambutol;
D O I：
10.1007/s00415-003-0960-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Primary mitochondrial DNA (mtDNA) mutation at the nt 11778 site in Leber's hereditary optic neuropathy (LHON) has been reported to be present in patients with ethambutol-induced optic neuropathy. To study further this association between LHON and ethambutol-induced optic neuropathy, we tested ethambutol-induced optic neuropathy patients for the presence of the mtDNA mutations at nucleotides (nt)-11778, nt-14484, nt-3460, nt-15257, nt-9438, nt-9804, nt-13730, and nt-14459 in 24, 15, 8, 6, 5, 5, 5, and 5 patients respectively. However, none of the ethambutol-induced optic neuropathy patients was found to exhibit any pathogenic LHON mtDNA mutation. In conclusion, we found no evidence of any association between ethambutol-induced optic neuropathy and the LHON mutations.
引用
收藏
页码：87 / 89
页数：3
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