Pronounced Orthostatic Hypotension in GBA-Related Parkinson's Disease

被引：4
|
作者：
Usnich, Tatiana [1 ]
Hanssen, Henrike [1 ,2 ]
Lohmann, Katja [1 ]
Lohse, Christina [2 ]
Klein, Christine [1 ]
Kasten, Meike [1 ,3 ]
Bruggemann, Norbert [1 ,2 ]
机构：
[1] Univ Lubeck, Inst Neurogenet, Lubeck, Germany
[2] Univ Lubeck, Dept Neurol, Lubeck, Germany
[3] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany
来源：
JOURNAL OF PARKINSONS DISEASE | 2022年 / 12卷 / 05期
关键词：
Autonomic symptoms; GBA; orthostatic hypotension; Parkinson's disease; MUTATIONS; SYMPTOMS; MOTOR;
D O I：
10.3233/JPD-223197
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Patients with Parkinson's disease (PD) carrying variants in the Glucocerebrosidase (GBA) gene (GBA-PD) suffer from orthostatic symptoms more frequently than idiopathic PD patients (IPD). Systematic measurements of the blood pressure have not yet been performed. In the present study, a prospective analysis of 33 GBA-PD and 313 IPD patients was carried out. Systolic blood pressure upon changing from the supine to the upright position dropped more strongly in GBA-PD compared to IPD patients. Diastolic blood pressure and heart rate did not differ between groups. This study provides further evidence for a pronounced involvement of the autonomic nervous system in GBA-PD.
引用
收藏
页码：1539 / 1544
页数：6
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