Ovariectomy decreases osteogenetic activity in rat bone

被引：0
|
作者：
Goseki, MS [1 ]
Omi, N [1 ]
Yamamoto, A [1 ]
Oida, S [1 ]
Ezawa, I [1 ]
Sasaki, S [1 ]
机构：
[1] JAPAN WOMENS UNIV, DEPT FOOD & NUTR, BUNKYO KU, TOKYO 112, JAPAN
来源：
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 1996年 / 42卷 / 01期
关键词：
alkaline phosphatase (ALP); ovariectomy (OVX); osteocalcin (BGP); bone morphogenetic protein (BMP); osteoinduction;
D O I：
暂无
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The purpose of this study was to investigate the effect of ovariectomy on osteoinductive activity in the bone in rat. Homograft implantation of decalcified humeral diaphysis from ovariectomized or sham-operated rats was performed and harvested after several time periods. A significant decrease in bone induction was found in terms of soft X-ray photography, alkaline phosphatase activity, mineral content and expression of osteocalcin (BGP; bone gla-protein) in the implants from the ovariectomized group in comparison to those from the sham-operated animals. This result suggested that the level of osteoinductive activity, probably due to bone morphogenetic protein, decreased in ovariectomized animals.
引用
收藏
页码：55 / 67
页数：13
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