Inhibition of extracellular signal-regulated kinase1/2 mitogen-activated protein kinase (MAPK/ERK1/2) activity by MEK1/2 inhibitor AZD6244 (ARRY-142886) induces human multiple myeloma (MM) cell apoptosis and inhibits osteoclasts within the bone marrow (BM) microenvironment

被引:0
|
作者
Tai, Y. T.
Hideshima, T.
Song, W.
Li, X. F.
Rumizen, M.
Burger, P.
Morrison, A.
Podar, K.
Schlossman, R.
Richardson, P.
Munshi, N. C.
Ghobrial, I.
Smith, P.
Anderson, K. C.
机构
[1] Harvard Med Sch, Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA 02115 USA
[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England
来源
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2007年 / 92卷 / 06期
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中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
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页码:147 / 147
页数:1
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