Creation of human thymidylate synthase mutants resistant to 5-fluorouracil.

被引：0
|
作者：
Landis, DM [1 ]
Loeb, LA [1 ]
机构：
[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA
来源：
JOURNAL OF INVESTIGATIVE MEDICINE | 1998年 / 46卷 / 01期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：90A / 90A
页数：1
相关论文
共 50 条
  • [1] Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 LOOP mutants of human thymidylate synthase
    Landis, DM
    Heindel, GC
    Loeb, LA
    CANCER RESEARCH, 2001, 61 (02) : 666 - 672
  • [2] Model chemical studies of thymidylate synthase. Nucleophilic addition of hydroxylamine to uracil and 5-fluorouracil.
    Costi, MP
    Rastelli, G
    Rinaldi, M
    Cevolani, M
    Pecorari, P
    FARMACO, 1996, 51 (03): : 209 - 214
  • [3] A nonsteady state model for the tight binding inhibition of thymidylate synthetase by 5-fluorouracil.
    DeWoskin, RS
    Setzer, RW
    TOXICOLOGICAL SCIENCES, 2003, 72 : 37 - 37
  • [4] THYMIDYLATE SYNTHASE GENE AMPLIFICATION IN HUMAN COLON-CANCER CELL-LINES RESISTANT TO 5-FLUOROURACIL
    COPUR, S
    AIBA, K
    DRAKE, JC
    ALLEGRA, CJ
    CHU, E
    BIOCHEMICAL PHARMACOLOGY, 1995, 49 (10) : 1419 - 1426
  • [5] 5-fluorouracil-mediated thymidylate synthase induction in malignant and nonmalignant human cells
    Parr, AL
    Drake, JC
    Gress, RE
    Schwartz, G
    Steinberg, SM
    Allegra, CJ
    BIOCHEMICAL PHARMACOLOGY, 1998, 56 (02) : 231 - 235
  • [6] INVITRO AND INVIVO INHIBITION OF THYMIDYLATE SYNTHASE OF HUMAN COLON CANCER BY 5-FLUOROURACIL
    PETERS, GJ
    LAURENSSE, EJ
    VANGROENINGEN, CJ
    MEIJER, S
    PINEDO, HM
    PURINE AND PYRIMIDINE METABOLISM IN MAN VI, PT A: CLINICAL AND MOLECULAR BIOLOGY, 1989, 253 : 439 - 445
  • [7] Detection and quantitation of thymidylate synthase mRNA in human colon adenocarcinoma cell line resistant to 5-fluorouracil by competitive PCR
    Shibata, J
    Aiba, K
    Shibata, H
    Minowa, S
    Horikoshi, N
    ANTICANCER RESEARCH, 1998, 18 (3A) : 1457 - 1463
  • [8] Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism
    Peters, GJ
    Backus, HHJ
    Freemantle, S
    van Triest, B
    Codacci-Pisanelli, G
    van der Wilt, CL
    Smid, K
    Lunec, J
    Calvert, AH
    Marsh, S
    McLeod, HL
    Bloemena, E
    Meijer, S
    Jansen, G
    van Groeningen, CJ
    Pinedo, HM
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2002, 1587 (2-3): : 194 - 205
  • [9] Association of thymidylate synthase variants with 5-fluorouracil cytotoxicity
    Peters, Eric J.
    Kraja, Aldi T.
    Lin, Shiow J.
    Yen-Revollo, Jane L.
    Marsh, Sharon
    Province, Michael A.
    McLeod, Howard L.
    PHARMACOGENETICS AND GENOMICS, 2009, 19 (05): : 399 - 401
  • [10] Thymidylate synthase and 5-fluorouracil - A cautionary tale - Commentary
    Bunz, Fred
    CANCER BIOLOGY & THERAPY, 2008, 7 (07) : 995 - 996
12345