tRNA-derived fragments as New Hallmarks of Aging and Age-related Diseases

被引：19
|
作者：
Yuan, Ya [1 ]
Li, Jiamei [1 ]
He, Zhi [1 ]
Fan, Xiaolan [1 ,2 ]
Mao, Xueping [1 ,2 ]
Yang, Mingyao [1 ,2 ]
Yang, Deying [1 ,2 ]
机构：
[1] Sichuan Agr Univ, Inst Anim Genet & Breeding, Chengdu 611130, Sichuan, Peoples R China
[2] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Sichuan, Peoples R China
来源：
AGING AND DISEASE | 2021年 / 12卷 / 05期
基金：
中国国家自然科学基金;
关键词：
tRFs; regulation mechanisms; aging; age-related diseases; PROMOTES CELL-PROLIFERATION; SMALL NONCODING RNAS; CYTOCHROME-C; LUNG-CANCER; TRANSLATION; MODEL; ROLES; RISK; BIOGENESIS; EXPRESSION;
D O I：
10.14336/AD.2021.0115
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
tRNA-derived fragments (tRFs), which are non-coding RNAs produced via tRNA cleavage with lengths of 14 to 50 nucleotides, originate from precursor tRNAs or mature tRNAs and exist in a wide range of organisms. tRFs are produced not by random fracture of tRNAs but by specific mechanisms. Considerable evidence shows that tRFs are detectable in model organisms of different ages and are associated with age-related diseases in humans, such as cancer and neurodegenerative diseases. In this literature review, the origin and classification of tRFs and the regulatory mechanisms of tRFs in aging and age-related diseases are summarized. We also describe the available tRF databases and research techniques and lay a foundation for the exploration of tRFs as biomarkers for the diagnosis and treatment of aging and age-related diseases.
引用
收藏
页码：1304 / 1322
页数：19
相关论文
共 50 条
  • [1] tRNA-derived fragments and tRNA halves: The new players in cancers
    Zhu, Linwen
    Ge, Jiaxin
    Li, Tianwen
    Shen, Yijing
    Guo, Junming
    CANCER LETTERS, 2019, 452 : 31 - 37
  • [2] Recent Insights Into Wnt-Related tRNA-Derived Fragments (tRFs) in Human Diseases
    Shen, Jinze
    Wang, Qurui
    Huang, Qinyuan
    Ying, Xiaowei
    Wang, Zehua
    Xu, Zhengfeng
    Dong, Jingyin
    Duan, Shiwei
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2025, 126 (01)
  • [3] Extracellular tRNAs and tRNA-derived fragments
    Tosar, Juan Pablo
    Cayota, Alfonso
    RNA BIOLOGY, 2020, 17 (08) : 1149 - 1167
  • [4] tRNA-derived fragments (tRFs) in cancer
    Pekarsky, Yuri
    Balatti, Veronica
    Croce, Carlo M.
    JOURNAL OF CELL COMMUNICATION AND SIGNALING, 2023, 17 (01) : 47 - 54
  • [5] tRNA-derived fragments (tRFs) in cancer
    Yuri Pekarsky
    Veronica Balatti
    Carlo M. Croce
    Journal of Cell Communication and Signaling, 2023, 17 : 47 - 54
  • [6] tRNA-derived fragments as new players in regulatory processes in yeast
    Tyczewska, Agata
    Grzywacz, Kamilla
    YEAST, 2023, 40 (08) : 283 - 289
  • [7] Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research Advancement
    Tenchov, Rumiana
    Sasso, Janet M.
    Wang, Xinmei
    Zhou, Qiongqiong Angela
    ACS CHEMICAL NEUROSCIENCE, 2023, 15 (01): : 1 - 30
  • [8] tRNA-Derived Fragments as Biomarkers in Bladder Cancer
    Stromme, Olaf
    Heck, Kathleen A.
    Brede, Gaute
    Lindholm, Havard T.
    Otterlei, Marit
    Arum, Carl-Jorgen
    CANCERS, 2024, 16 (08)
  • [9] tRFTars: predicting the targets of tRNA-derived fragments
    Xiao, Qiong
    Gao, Peng
    Huang, Xuanzhang
    Chen, Xiaowan
    Chen, Quan
    Lv, Xinger
    Fu, Yu
    Song, Yongxi
    Wang, Zhenning
    JOURNAL OF TRANSLATIONAL MEDICINE, 2021, 19 (01)
  • [10] tRFTars: predicting the targets of tRNA-derived fragments
    Qiong Xiao
    Peng Gao
    Xuanzhang Huang
    Xiaowan Chen
    Quan Chen
    Xinger Lv
    Yu Fu
    Yongxi Song
    Zhenning Wang
    Journal of Translational Medicine, 19
12345