The Probe Length Effect on the Cantilever of an Atomic Force Microscope in Measuring the Mechanical Properties of Living Neurons

被引：7

作者：

Ankudinov, A. V. ^{[1
,2
]}

Khalisov, M. M. ^{[2
,3
]}

Penniyaynen, V. A. ^{[3
]}

Podzorova, S. A. ^{[3
]}

Timoshchuk, K. I. ^{[2
,3
]}

Krylov, B. V. ^{[3
]}

机构：

[1] Russian Acad Sci, Ioffe Phys Tech Inst, Politekhnicheskaya Ul 26, St Petersburg 194021, Russia

[2] St Petersburg Natl Res Univ Informat Technol Mech, St Petersburg 197101, Russia

[3] Pavlov Inst Physiol, St Petersburg 199034, Russia

来源：

TECHNICAL PHYSICS LETTERS | 2018年 / 44卷 / 08期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1134/S1063785018080035

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Living sensory neurons were studied by atomic force microscopy in the PeakForce QNM mode under near-physiological conditions. The dependence of the measured apparent Young modulus of cells on the ratio of the probe height to the beam length on a used cantilever was revealed. A qualitative explanation based on the analysis of beam strains in two limit cases, in which the probe slides over a studied object and the probe sticks to the latter, was given to the obtained result. It was proposed to classify native cells by the character of their interaction with the probe (sliding or sticking).

引用

页码：671 / 674

页数：4

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