Multicomponent Synthesis of α-Branched Tertiary and Secondary Amines by Photocatalytic Hydrogen Atom Transfer Strategy

被引：35
|
作者：
Qi, Xu-Kuan [1 ]
Guo, Lin [1 ]
Yao, Li-Juan [1 ]
Gao, Han [1 ]
Yang, Chao [1 ]
Xia, Wujiong [1 ,2 ]
机构：
[1] Harbin Inst Technol Shenzhen, Sch Sci, State Key Lab Urban Water Resource & Environm, Shenzhen 518055, Peoples R China
[2] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 11期
基金：
中国国家自然科学基金;
关键词：
REDUCTIVE AMINATION;
D O I：
10.1021/acs.orglett.1c01412
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A multicomponent carbonyl alkylative amination reaction is described. A variety of N-arylamines, aldehydes, and hydrocarbons have been examined as reaction substrates using tetrabutylammonium decatungstate as photocatalyst, providing the corresponding alpha-branched tertiary and secondary amines in good to moderate yields. The reaction proceeds through the generation of alkyl radicals by a light-promoted hydrogen atom transfer process followed by free radical addition to iminium ions generated in situ.
引用
收藏
页码：4473 / 4477
页数：5
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