Bone Tissue Engineering: Natural Origination Or Synthetic Polymeric Scaffolds?
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Danti, Serena
[1
,4
]
Lisanti, Michele
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机构:
Univ Pisa, Ind Med, Dept Endocrinol & Metabolism Orthoped & Traumatol, I-56124 Pisa, ItalyUniv Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, Italy
Lisanti, Michele
[2
]
Berrettini, Stefano
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Univ Pisa, Dept Neurosci, ENT Unit, I-56124 Pisa, ItalyUniv Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, Italy
Berrettini, Stefano
[3
]
Petrini, Mario
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Univ Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, Italy
Univ Pisa, CUCCS, I-56126 Pisa, ItalyUniv Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, Italy
Petrini, Mario
[1
,4
]
Pietrabissa, Andrea
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Univ Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, ItalyUniv Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, Italy
Pietrabissa, Andrea
[1
]
机构:
[1] Univ Pisa, Dept Oncol Transplantat & New Technol Med, Via Roma 55, I-56126 Pisa, Italy
Cancellous Bone Grafts;
Demineralized Bone Matrix;
Mesenchymal Stem Cells;
Polymeric Scaffolds;
Bone Tissue Engineering;
D O I:
10.4028/www.scientific.net/AMR.15-17.65
中图分类号:
O414.1 [热力学];
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摘要:
The aim of this report was to investigate the behavior of human mesenchymal stem cells (hMSCs) when cultured on different porous 3D scaffolds, having natural or synthetic origination. Natural scaffolds were obtained by hand made processing of human bone tissue (allograft), because its well known osteoconductive features, using different procedures to eliminate the donor cellular phase. Cancellous bone was frozen, heated or demineralized before being loaded with hMSCs. Among the variety of synthetic materials, biodegradable polymeric spongy matrices were chosen and comparatively tested as scaffolds for hMSCs growth.
机构:
Fuzhou Univ, Inst Biomed & Pharmaceut Technol, 523 Gongye Rd, Fuzhou 350002, Fujian, Peoples R China
Columbia Univ, Coll Dent Med, New York, NY 10032 USAFuzhou Univ, Inst Biomed & Pharmaceut Technol, 523 Gongye Rd, Fuzhou 350002, Fujian, Peoples R China
Chen, Jingdi
Zhang, Qiqing
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Fuzhou Univ, Inst Biomed & Pharmaceut Technol, 523 Gongye Rd, Fuzhou 350002, Fujian, Peoples R China
Chinese Acad Med Sci, Inst Biomed Engn, Tianjin 300192, Peoples R China
Peking Union Med Coll, Tianjin 300192, Peoples R ChinaFuzhou Univ, Inst Biomed & Pharmaceut Technol, 523 Gongye Rd, Fuzhou 350002, Fujian, Peoples R China