Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers

被引：9
|
作者：
Kardumyan, Valeriya V. [1 ]
Aksenova, Nadejda A. [1 ,2 ]
Timofeeva, Victoria A. [1 ]
Krivandin, Alexey V. [3 ]
Shatalova, Olga V. [3 ]
Dubovik, Alexander S. [3 ,4 ]
Plashchina, Irina G. [3 ]
Timashev, Peter S. [1 ,2 ,5 ]
Solovieva, Anna B. [1 ]
机构：
[1] Russian Acad Sci, NN Semenov Fed Res Ctr Chem Phys, Kosygin St 4, Moscow 119991, Russia
[2] Sechenov First Moscow State Med Univ, Sechenov Univ, Inst Regenerat Med, 8-2 Trubetskayast, Moscow 119991, Russia
[3] Russian Acad Sci, NM Emanuel Inst Biochem Phys, Kosygin St 4, Moscow 119334, Russia
[4] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Vavilov St 28, Moscow 119991, Russia
[5] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119334, Russia
来源：
POLYMERS | 2021年 / 13卷 / 07期
基金：
俄罗斯基础研究基金会;
关键词：
chitosan; porphyrin; Pluronic F127; polyvinylpyrrolidone; tryptophan photo-oxidation; PHOTOCATALYTIC ACTIVITY; SINGLET OXYGEN; CONFORMATION;
D O I：
10.3390/polym13071007
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw similar to 100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127.
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页数：14
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