Impact of tumor size on hepatectomy outcomes in hepatocellular carcinoma: a nationwide propensity score matching analysis

被引:10
|
作者
Hong, Suk Kyun [1 ]
Lee, Kwang-Woong [1 ]
Lee, Sola [1 ]
Hong, Su Young [1 ]
Suh, Sanggyun [1 ]
Han, Eui Soo [1 ]
Choi, YoungRok [1 ]
Yi, Nam-Joon [1 ]
Suh, Kyung-Suk [1 ]
机构
[1] Seoul Natl Univ, Dept Surg, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea
关键词
Disease progression; Hepatectomy; Hepatocettular carcinoma; Survival; LIVER RESECTION; PROGNOSTIC-FACTORS; ALPHA-FETOPROTEIN; 10; CM; SURVIVAL; LARGER; DIAGNOSIS; INVASION; SAFETY; COHORT;
D O I
10.4174/astr.2022.102.4.193
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose: The aim of this study was to compare surgical outcomes after liver resection for hepatocellular carcinoma (HCC) according to tumor size using a large, nationwide cancer registry-based cohort and propensity score matching. Methods: From 2008 to 2015, a total of 12,139 patients were diagnosed with liver cancer and registered in the Korean Primary Liver Cancer Registry. Patients without distant metastasis who underwent hepatectomy as a primary treatment were selected. We performed 1:1 propensity score matching between the small (<5 cm), large (>= 5 cm and <10 cm), and huge (>= 10 cm) groups. Results: Overall, 265 patients in the small and large groups were compared, and 64 patients each in the large and huge groups were compared. The overall and progression-free survival rates were significantly lower in the large group than in the small group (P < 0.001 and P < 0.001, respectively). Overall survival tended to be poorer in the huge group than in the large group (P = 0.051). The progression-free survival rate was significantly lower in the huge group than in the large group (P = 0.002). Conclusion: Although primary liver resection can be considered even in patients with huge HCC, greater caution with careful screening for recurrence is needed.
引用
收藏
页码:193 / 204
页数:12
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