Solubility of Isoniazid in Supercritical Carbon Dioxide

被引：18
|
作者：
Heryanto, Rudi [1 ,2 ]
Abdullah, Ezzat Chan [1 ]
Hasan, Masitah [1 ]
机构：
[1] Univ Malaya, Fac Engn, Dept Chem Engn, Kuala Lumpur 50603, Malaysia
[2] Bogor Agr Univ, Dept Chem, Fac Math & Nat Sci, Bogor, Indonesia
来源：
JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2010年 / 55卷 / 06期
关键词：
PULMONARY DELIVERY; DRUG-DELIVERY; SOLIDS;
D O I：
10.1021/je900622h
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
Solubility data of isoniazid in supercritical carbon dioxide are important in selecting the most appropriate supercritical methods for pharmaceutical material processing, such as the micronization of isoniazid or the production of isoniazid composites. The solubility of isoniazid in supercritical carbon dioxide was measured using a dynamic analytical method at temperatures of (308, 311, and 313) K and pressures ranging from (13.0 to 18.5) MPa. The result showed that isoniazid solubility increased with the increase of pressure at an isothermal condition and it also increased with the increase of temperature. The experimental data were correlated using the Chrastil and Mendez-Santiago and Teja models. The calculated results show good agreement with the experimental data.
引用
收藏
页码：2306 / 2309
页数：4
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