Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase

被引：62

作者：

Cumming, JG ^{[1
]}

McKenzie, CL ^{[1
]}

Bowden, SG ^{[1
]}

Campbell, D ^{[1
]}

Masters, DJ ^{[1
]}

Breed, J ^{[1
]}

Jewsbury, PJ ^{[1
]}

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 21期

关键词：

p38 MAP kinase inhibitors;

D O I：

10.1016/j.bmcl.2004.08.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

SAR studies led to the identification of 4-(3-benzoylamino-6-methyl-anilino)quinazolines as potent and selective inhibitors of p38 MAP kinase. Further optimisation led to the identification of a series of 4-(3-benzoylamino-6-methyl-anilino)pyr midines as potent inhibitors of the p38 MAP kinase signalling pathway in vitro and in vivo. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5389 / 5394

页数：6

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