Influenza A M2 transmembrane domain tunes its conformational heterogeneity and structural plasticity in the lipid bilayer by forming loop structures

被引：18
|
作者：
Liu, Yue
Tan, Junjun
Zhang, Jiahui
Li, Chuanzhao
Luo, Yi
Ye, Shuji [1 ]
机构：
[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 46期
关键词：
SOLID-STATE NMR; PROTON CHANNEL; VIBRATIONAL SPECTROSCOPY; SUM-FREQUENCY; CONDUCTION MECHANISM; HELIX TILT; VIRUS; MEMBRANE; ORIENTATION; ACTIVATION;
D O I：
10.1039/c8cc01533c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We discovered for the first time that the influenza A virus M2TM tunes its conformational heterogeneity and structural plasticity to respond to environmental cues by undergoing a helix-to-loop transition, resolving controversies regarding the mechanism of proton conduction and plasticity of the M2TM in lipid bilayers.
引用
收藏
页码：5903 / 5906
页数：4
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