Comparative in vitro activity of oral antimicrobial agents against Enterobacteriaceae from patients with community-acquired urinary tract infections in three European countries

被引：35

作者：

Kresken, M. ^{[1
]}

Koerber-Irrgang, B. ^{[1
]}

Biedenbach, D. J. ^{[2
]}

Batista, N. ^{[3
]}

Besard, V. ^{[4
]}

Canton, R. ^{[5
,6
]}

Garcia-Castillo, M. ^{[5
,6
]}

Kalka-Moll, W. ^{[7
]}

Pascual, A. ^{[3
]}

Schwarz, R. ^{[7
]}

Van Meensel, B. ^{[8
]}

Wisplinghoff, H. ^{[9
]}

Seifert, H. ^{[10
,11
]}

机构：

[1] Antiinfect Intelligence GmbH, D-53359 Rheinbach, Germany

[2] Int Hlth Management Associates Inc, Schaumburg, IL USA

[3] Hosp Univ Virgen Macarena, Microbiol Serv, Seville, Spain

[4] Practimed CVBA Clin Lab, Tessenderlo, Belgium

[5] Hosp Ramon & Cajal, Microbiol Serv, E-28034 Madrid, Spain

[6] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain

[7] Med Versorgungszentrum Dr Stein & Kollegen, Monchengladbach, Germany

[8] MCH Leuven, Leuven, Belgium

[9] Lab Med Koln Dres Med Wisplinghoff & Kollegen, Cologne, Germany

[10] Univ Cologne, Inst Med Microbiol Immunol & Hyg, D-50931 Cologne, Germany

[11] German Ctr Infect Res, Bonn, Germany

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2016年 / 22卷 / 01期

关键词：

Age; cephalosporin; extended-spectrum beta-lactamase rates; gender; resistance; ESCHERICHIA-COLI; BETA-LACTAMASES; RESISTANCE; SUSCEPTIBILITY; TRIMETHOPRIM; ANTIBIOTICS; PATHOGENS; EVOLUTION; THERAPY;

D O I：

10.1016/j.cmi.2015.08.019

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Enterobacteriaceae causing community-acquired urinary tract infections were examined in selected outpatient clinics and hospitals in Belgium, Germany and Spain using EUCAST breakpoints for susceptibility. A total of 1190 isolates were collected. Escherichia coli isolates were resistant to amoxicillin-clavulanic acid (28.1%), ciprofloxacin (23.4%) and trimethoprim-sulfamethoxazole (21.4%) compared with fosfomycin and nitrofurantoin (each, < 1.5%). Ceftibuten (MIC50/90 0.25/0.5 mg/L) and ceftriaxone activity (MIC50/90 <= 0.25 mg/L) was comparable. Ceftibuten (MIC90 <= 0.25 mg/L) was also active against Proteus mirabilis and Klebsiella spp. Extended-spectrum beta-lactamase phenotypes were 7.1% for E. coli, 5.6% for Klebsiella pneumoniae and 0.4% for P. mirabilis. Resistance was common among men and elderly women. (C) 2015 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：63.e1 / 63.e5

页数：5

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