The molecular basis of voltage-gated Ca2+ channel diversity:: Is it time for T?

被引：62
|
作者：
Randall, AD [1 ]
机构：
[1] MRC, Mol Biol Lab, Div Neurobiol, Cambridge CB2 2QH, England
来源：
JOURNAL OF MEMBRANE BIOLOGY | 1998年 / 161卷 / 03期
关键词：
calcium channels; pharmacology; cloning; review; ion channels;
D O I：
10.1007/s002329900327
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The existence of diversity in the voltage activated Ca2+ channel populations of vertebrate cells has been long recognized. More recently, the molecular cloning of a considerable number of Ca2+ channel subunits from cDNA libraries has indicated that the range of possible Ca2+ channel phenotypes a cell can express may be even greater than was previously appreciated. A challenge of recent years has been to resolve how the properties of recombinant channels correspond with their counterparts experimentally characterized in native cells. In this shea review I will outline the properties of both native and recombinant Ca2+ channels, and will then describe the current agreements and controversies concerning their relationships to each other.
引用
收藏
页码：207 / 213
页数：7
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