Inhibiting the Mitochondrial Permeability Transition by Targeting Cyclophilin D Enhances Beta Cell Survival and Prevents Diabetes in Pdx1 Insufficiency

被引:0
|
作者
Fujimoto, Kei
Chen, Yun
Polonsky, Kenneth S.
Dorn, Gerald W., II
机构
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:A49 / A49
页数:1
相关论文
共 37 条
  • [1] Targeting cyclophilin D and the mitochondrial permeability transition enhances β-cell survival and prevents diabetes in Pdx1 deficiency
    Fujimoto, Kei
    Chen, Yun
    Polonsky, Kenneth S.
    Dorn, Gerald W., II
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (22) : 10214 - 10219
  • [2] Mitochondrial permeability transition and cell death: the role of cyclophilin D
    Javadov, Sabzali
    Kuznetsov, Andrey
    FRONTIERS IN PHYSIOLOGY, 2013, 4
  • [3] Pdx1 Modulates Pancreatic Beta Cell Survival Via Nix Expression
    Fujimoto, Kei
    Hanson, Piia T.
    Ford, Eric L.
    Tran, Hung
    Dorn, Gerald W., II
    Wice, Burton M.
    Polonsky, Kenneth S.
    DIABETES, 2009, 58 : A404 - A404
  • [4] MST1 mediates beta cell failure by targeting BIM and destabilising PDX1
    Ardestani, A.
    Paroni, F.
    Kerr-Conte, J.
    Maedler, K.
    DIABETOLOGIA, 2012, 55 : S218 - S218
  • [5] Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration
    Detaille, D.
    Vial, G.
    Borel, A-L
    Cottet-Rouselle, C.
    Hallakou-Bozec, S.
    Bolze, S.
    Fouqueray, P.
    Fontaine, E.
    CELL DEATH DISCOVERY, 2016, 2
  • [6] Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration
    D Detaille
    G Vial
    A-L Borel
    C Cottet-Rouselle
    S Hallakou-Bozec
    S Bolze
    P Fouqueray
    E Fontaine
    Cell Death Discovery, 2
  • [7] Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta
    Du, Heng
    Yan, Shirley ShiDu
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2010, 1802 (01): : 198 - 204
  • [8] Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D
    Lindblom, Runa S. J.
    Higgins, Gavin C.
    Tuong-Vi Nguyen
    Arnstein, Maryann
    Henstridge, Darren C.
    Granata, Cesare
    Snelson, Matthew
    Thallas-Bonke, Vicki
    Cooper, Mark E.
    Forbes, Josephine M.
    Coughlan, Melinda T.
    CLINICAL SCIENCE, 2020, 134 (02) : 239 - 259
  • [9] Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
    Baines, CP
    Kaiser, RA
    Purcell, NH
    Blair, NS
    Osinska, H
    Hambleton, MA
    Brunskill, EW
    Sayen, MR
    Gottlieb, RA
    Dorn, GW
    Robbins, J
    Molkentin, JD
    NATURE, 2005, 434 (7033) : 658 - 662
  • [10] Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death
    Christopher P. Baines
    Robert A. Kaiser
    Nicole H. Purcell
    N. Scott Blair
    Hanna Osinska
    Michael A. Hambleton
    Eric W. Brunskill
    M. Richard Sayen
    Roberta A. Gottlieb
    Gerald W. Dorn
    Jeffrey Robbins
    Jeffery D. Molkentin
    Nature, 2005, 434 : 658 - 662