Sensitization of lymphocytes to insulin as one of risk factors of ischemic heart disease

Prevalence and character of sensitization of lymphocytes to insulin and its prognostic significance were studied in 71 patients with ischemic heart disease and 55 healthy people. Direct overt sensitization of lymphocytes to insulin was found in 14 of 71 patients (p<0.01 compared with control group). This type of reaction was associated with myocardial infarction. Concealed indirect reaction of lymphocytes to insulin was revealed at inhibition of cells with receptors to histamine or prostaglandin synthesizing cells in 13 and 19 of 71 patients, respectively (p<0.01 and p<0.05 compared with control group). Direct overt sensitization of lymphocytes to insulin and concealed indirect sensitization revealed at inhibition of functional activity of cells with receptors to histamine serve as prognostically unfavorable factors because they are associated with development of heart failure and higher rate of lethal outcome.