Controllable performance of a dopamine-modified silk fibroin-based bio-adhesive by doping metal ions

被引:12
|
作者
Yin, Zichu [1 ]
Liu, Han [1 ]
Lin, Minjie [1 ]
Xie, Wenjiao [1 ]
Yang, Xiaogang [2 ]
Cai, Yurong [1 ]
机构
[1] Zhejiang Sci Tech Univ, Key Lab Adv Text Mat & Mfg Technol, Minist Educ, Natl Engn Lab Text Fiber Mat & Proc Technol,Sch M, Hangzhou 310018, Peoples R China
[2] Zhejiang Sci Tech Univ, Acad Sci & Technol, Hangzhou 310018, Peoples R China
关键词
silk fibroin; bio-adhesive; stickiness; modify; gelation; TISSUE ADHESIVE; BIOADHESIVE;
D O I
10.1088/1748-605X/ac0087
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Bio-adhesives are essential for wound healing because of their convenience and safety. Although widely used as biomaterials, silk fibroin's (SF's) further application as bio-adhesive is hindered due to its weak stickiness with tissue and slow gelation speed. Here, a dopamine-modified SF-based bio-adhesive is fabricated by using genipin as the chemical cross-linking agent. Furthermore, metal ions have been used to adjust the adhesion property of the bio-adhesive. The experimental results shows that the dopamine-modified SF-based composite holds a better stickiness except slow gelation speed. The doping of Cu2+ and Fe3+ can accelerate the gelation of the bio-adhesive. Compared with Cu2+, Fe3+ has a stronger effect on the gelation speed of the bio-adhesive, which is positive correlative to the concentration of Fe3+. The adhesive has injectability and degradability. In addition, the SF-based adhesive has good biocompatibility and good improvement for cell migration in vitro. The SF-based bio-adhesive holds potential application in the field of rapid fixation of wounds.
引用
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页数:11
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