Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells

被引：31

作者：

Fialova, Anna ^{[1
]}

Cimburek, Zdenek ^{[2
]}

Iezzi, Giandomenica ^{[3
]}

Kopecky, Jan ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Ctr Biol, Inst Parasitol, CZ-37005 Ceske Budejovice, Czech Republic

[2] Acad Sci Czech Republic, Inst Microbiol, Ctr Flow Cytometry, CZ-14220 Prague 4, Czech Republic

[3] Univ Basel Hosp, Inst Surg Res, CH-4031 Basel, Switzerland

来源：

MICROBES AND INFECTION | 2010年 / 12卷 / 07期

关键词：

Tick-borne encephalitis virus; Dendritic cell; Tick saliva; Ixodes ricinus; LANGERHANS CELLS; TRANSMISSION; SKIN; ENHANCEMENT; MATURATION; MIGRATION;

D O I：

10.1016/j.micinf.2010.03.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tick-borne encephalitis virus is an important human pathogen, naturally delivered into host skin via a tick bite. To examine the effects of the virus on dendritic cell biology, we cultured dendritic cells with two tick-borne encephalitis virus strains of different virulence in the presence of Ixodes ricinus tick saliva. Tick saliva treatment increased proportion of virus-infected cells, led to a decrease in virus-induced TNF-alpha and IL-6 production and to reduced virus-induced apoptosis. Our data indicate that tick saliva modulate virus-mediated alterations in dendritic cells, thus probably being involved in the early infection process in the host. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：580 / 585

页数：6

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