Nivolumab-Induced Pneumonitis in Patient With Metastatic Melanoma Showing Complete Remission on 18F-FDG PET/CT

被引：8
|
作者：
Razzouk-Cadet, Micheline [1 ]
Picard, Alexandra [2 ]
Grangeon-Chapon, Caroline [1 ,3 ]
Lacour, Jean-Philippe [2 ,4 ]
Montaudie, Henri [2 ,4 ]
机构：
[1] CHU Nice, Dept Nucl Med, Archet 151,Route St Antoine Ginestiere, F-06200 Nice 3, France
[2] CHU Nice, Dept Dermatol, Nice, France
[3] CHU Nice, Dept Pharm, Nice, France
[4] INSERM, U1065, Equipe 12 C3M, Nice, France
来源：
CLINICAL NUCLEAR MEDICINE | 2019年 / 44卷 / 10期
关键词：
F-18-FDG PET/CT; anti-PD1; complete remission; metastatic melanoma; pneumonitis; pseudoprogression; IPILIMUMAB;
D O I：
10.1097/RLU.0000000000002707
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
A 49-year-old patient with metastatic melanoma was treated with nivolumab (Opdivo). An early F-18-FDG PET/CT after 2 cycles showed a progressive metabolic disease. A 4-month optimal follow-up F-18-FDG PET/CT showed a complete metabolic response. The treatment was stopped after 22 cycles because of immunotherapy-related pneumonitis. After discontinuation of treatment, PET/CT examinations demonstrated a metabolic complete remission during 2 years. The metabolic pattern on early PET was suggestive of pseudoprogression, which is a rare phenomenon reflecting an activation of inflammatory cells within the tumor microenvironment causing lesions to increase in size and to accumulate FDG until a sufficient immune response is developed.
引用
收藏
页码：806 / 807
页数：2
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