Alteration in Serum Lipid Profile Pattern in Oral Squamous Cell Carcinoma and Potentially Malignant Disorders

Objective: To evaluate and compare lipid profile level in oral submucous fibrosis (OSMF), oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC) patients. Material and Methods: Thirty histopathologically diagnosed subjects each of OL, OSMF, OSCC were recruited along with 30 healthy controls. 5ml of venous blood is collected and estimated using standard diagnostic kits. Results: The mean of Total cholesterol level in controls was 219.03 mg%, in OSCC, OL and OSMF was 142.89 +/- 10.21 mg%, 155.44 +/- 17.63 mg% and 180.60 +/- 13.25 mg%, respectively. The mean low-density lipid level in controls was 137.24 mg and in OSCC, OL and OSMF groups were 109.28 +/- 2.16 mg%, 126.63 +/- 0.85 mg% and 119.15 +/- 0.93 mg%, respectively. The mean of high-density lipid level in controls, OSCC, OL and OSMF was 42.87 +/- 0.42 mg%, 36.50 +/- 2.31 mg%, 21.13 +/- 0.77 mg% and 28.37 +/- 1.11 mg%, respectively. The mean of very low density lipids level in controls, OSCC, OL and OSMF was 30.12 +/- 1.51 mg%, 17.24 +/- 0.80 mg%, 22.25 +/- 0.93 mg% and 25.89 +/- 0.43 mg%, respectively. The mean triglyceride level in controls, OSCC, OL and OSMF was 118.80 +/- 9.47 mg%, 91.2 +/- 3.03 mg%, 105.05 +/- 2.96 mg% and 106.19 +/- 3.09 mg%, respectively. Conclusion: Lipid profile levels could be early indicators of precancer and cancer.