An improved synthesis of 2-(1,2,4-thiadiazol-5-yl)pyridine by interception of an intermediate involved in a competing cyclisation reaction

被引：6
|
作者：
Richardson, Chris [1 ]
Steel, Peter J. [1 ]
机构：
[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 26期
关键词：
N-ligand; 1,2,4-thiadiazole; imidazo[1,5-a]pyridine;
D O I：
10.1016/j.tetlet.2007.04.140
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of thiopicolinamide with N,N'-dimethylformamide dimethyl acetal leads to the formation of 3-(dimethylamino)-1-methylthioimidazo[1,5-a]pyridine (3). However, the course of the reaction can be diverted to produce the title compound (1) in good yield by timely interception of the intermediate thioacylamidine (2). (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4553 / 4555
页数：3
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