Pd(II)-Catalyzed Synthesis of Carbolines by Iminoannulation of Internal Alkynes via Direct C-H Bond Cleavage Using Dioxygen as Oxidant

被引：124
|
作者：
Ding, Shengtao [1 ]
Shi, Zhuangzhi [1 ]
Jiao, Ning [1 ,2 ]
机构：
[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 07期
基金：
美国国家科学基金会;
关键词：
PALLADIUM-CATALYZED IMINOANNULATION; ANNULATED GAMMA-CARBOLINES; BETA-CARBOLINE; MOLECULAR-OXYGEN; ORGANIC-CHEMICALS; A-C; ALKALOIDS; DERIVATIVES; INDOLES; FUNCTIONALIZATION;
D O I：
10.1021/ol100272s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A palladium-catalyzed iminoannulation of Internal alkynes via direct C-H bond cleavage was developed. Dioxygen was employed as a clean oxidant In this kind of catalysis. Carbolines were synthesized from tert-butylimines of N-substituted Indole-2-carboxaldehydes or indole-3-carboxaldehydes.
引用
收藏
页码：1540 / 1543
页数：4
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