Protective effect of chrysin in rats subchronically exposed to sodium fluoride

The aim of this study was to examine the influence of the flavonoid chrysin on the morphology and histochemistry of rat liver and kidneys during subchronic exposure to sodium fluoride. Fluoride intoxication produced hepatocellular and focal necrosis with distension of central veins and sinusoids, necrosis of the renal cortex, and lesions in renal tubules in the form of vacuolar degeneration, metaplasia, and hyperplasia. Histochemical evidence for inhibition of succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH) in the liver, as well as SDH and alkaline phosphatase (AIP) in kidneys was obtained. Chrysin, particularly at 20 mg/kg body weight, offered protection against lesions and normalized enzyme activities in the liver and kidneys of rats intoxicated with fluoride.