The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

被引：25
|
作者：
Narayansingh, GV
Miller, ID
Sharma, M
Welch, CJ
Sharp, L
Parkin, DE
Cruickshank, ME
机构：
[1] Aberdeen Royal Infirm, Gynaecol Oncol Unit, Aberdeen AB25 2ZN, Scotland
[2] Aberdeen Royal Infirm, Dept Pathol, Aberdeen AB25 2ZN, Scotland
[3] Aberdeen Royal Infirm, Dept Epidemiol, Aberdeen AB25 2ZN, Scotland
来源：
BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 02期
关键词：
vulval cancer; groin nodes; micrometastases;
D O I：
10.1038/sj.bjc.6602343
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma ( SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node- negative SCC from a population- based cohort of Grampian women. Median follow- up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women ( 42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20- fold higher in those with micrometastases compared to those without ( hazard ratio = 19.6 ( 95% CI 2.3 - 171).
引用
收藏
页码：222 / 224
页数：3
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