Copper-Catalyzed Cycloisomerization of Cyclopropenylimine for Synthesis of Pyrroles

被引：10
|
作者：
Konishi, Keiji [1 ]
Takeda, Norihiko [1 ]
Yasui, Motohiro [1 ]
Matsuzaki, Haruo [1 ]
Miyata, Okiko [1 ]
Ueda, Masafumi [1 ]
机构：
[1] Kobe Pharmaceut Univ, Kobe, Hyogo 6588558, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 21期
关键词：
GOLD(I)-CATALYZED CYCLOISOMERIZATION; INTRAMOLECULAR CYCLIZATIONS; STEREOSELECTIVE-SYNTHESIS; ELECTROPHILIC ACTIVATION; METAL CARBENOIDS; REARRANGEMENT; GOLD; CONSTRUCTION; DERIVATIVES; CHEMISTRY;
D O I：
10.1021/acs.joc.9b02178
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed cycloisomerization of 3-iminocyclopropenes for synthesis of pyrroles has been developed. The reaction allows regioselective construction of pyrroles with various substitution patterns, including fully substituted pyrroles. The method was successfully applied to synthesis of steroidal pyrroles as well as a N-fused pyrrole.
引用
收藏
页码：14320 / 14329
页数：10
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