Enhancement of radiation effect by heavy elements

被引：154
|
作者：
Kobayashi, K. [1 ]
Usami, N. [1 ]
Porcel, E. [2 ]
Lacombe, S. [2 ]
Le Sech, C. [2 ]
机构：
[1] Natl Lab High Energy Phys, KEK, Tsukuba, Ibaraki 305, Japan
[2] Univ Paris 11, Orsay, France
来源：
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2010年 / 704卷 / 1-3期
关键词：
Radiobiological enhancement; Auger effect; Heavy elements; Nanoparticle; Cancer therapy; PLATINUM-CONTAINING MOLECULES; STRAND BREAK INDUCTION; X-RAY; GOLD NANOPARTICLES; DNA; ABSORPTION; ENERGY; CELLS; IRRADIATION; BROMINE;
D O I：
10.1016/j.mrrev.2010.01.002
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The enhancement of radiobiological effects by heavy elements is reviewed. As an underlying mechanism, Auger effects have been stressed which can be induced via inner-shell photoabsorption or via excitation and/or ionization by secondary electrons. Latter channel of Auger induction expands the applicability of Auger enhancing phenomena to electron and hadron therapy. After discussion on the required characteristics for radiosensitizers, possibility of nanoparticles of Au or Pt is mentioned since they could be synthesized or modified as ideal radiosensitizers. (C) 2010 Elsevier B.V. All rights reserved.
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页码：123 / 131
页数：9
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