When two are better than one: Bilateral mesial temporal lobe contributions associated with better vocabulary skills in children and adolescents

被引：14

作者：

Bartha-Doering, Lisa ^{[1
]}

Novak, Astrid ^{[1
]}

Kollndorfer, Kathrin ^{[1
,2
]}

Kasprian, Gregor ^{[2
]}

Schuler, Anna-Lisa ^{[1
]}

Berl, Madison M. ^{[3
]}

Fischmeister, Florian Ph S. ^{[4
]}

Gaillard, William D. ^{[3
]}

Alexopoulos, Johanna ^{[5
]}

Prayer, Daniela ^{[2
]}

Seidl, Rainer ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Pediat & Adolescent Med, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[3] George Washington Univ, Sch Med, CNHS, Ctr Neurosci & Behav Hlth, 111 Michigan Ave NW, Washington, DC 20010 USA

[4] Karl Franzens Univ Graz, Inst Psychol, Univ Pl 2, A-8010 Graz, Austria

[5] Med Univ Vienna, Dept Psychoanal & Psychotherapy, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

来源：

BRAIN AND LANGUAGE | 2018年 / 184卷

基金：

奥地利科学基金会;

关键词：

Functional neuroimaging; Hippocampus; Parahippocampalgyrus; Language; Cognitive function; HEMISPHERIC LANGUAGE REORGANIZATION; HIPPOCAMPAL DENTATE GYRUS; SEMANTIC MEMORY; FUNCTIONAL MRI; EPISODIC MEMORY; FMRI FINDINGS; GRAY-MATTER; LATERALIZATION; BRAIN; ACTIVATION;

D O I：

10.1016/j.bandl.2018.06.001

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

This study considered the involvement of the mesial temporal lobe (MTL) in language and verbal memory functions in healthy children and adolescents. We investigated 30 healthy, right-handed children and adolescents, aged 7-16, with a fMRI language paradigm and a comprehensive cognitive test battery. We found significant MU activations during language fMRI in all participants; 63% of them had left lateralized MTL activations, 20% exhibited right MTL lateralization, and 17% showed bilateral MTL involvement during the fMRI language paradigm. Group analyses demonstrated a strong negative correlation between the lateralization of MTL activations and language functions. Specifically, children with less lateralized MTL activation showed significantly better vocabulary skills. These findings suggest that the mesial temporal lobes of both hemispheres play an important role in language functioning, even in right-handers. Our results furthermore show that bilateral mesial temporal lobe involvement is advantageous for vocabulary skills in healthy, right-handed children and adolescents.

引用

页码：1 / 10

页数：10

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