Unexpected Toxicity of Cyclophosphamide Followed by Adoptively Transferred CD19-Targeted T Cells in a Patient with Bulky CLL

被引：0
|
作者：
Brentjens, Renier J. [1 ]
Riviere, Isabelle [1 ]
Hollyman, Daniel [1 ]
Taylor, Clare [1 ]
Nikhamin, Yan [1 ]
Stefanski, Jolanta [1 ]
Lee, James [1 ]
Yeh, Raymond [1 ]
Santos, Elmer [1 ]
Sadelain, Michel [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA
来源：
MOLECULAR THERAPY | 2009年 / 17卷
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
401
引用
收藏
页码：S157 / S157
页数：1
相关论文
共 50 条
  • [1] Enhanced In Vivo activation of Adoptively Transferred Genetically Targeted T Cells Following Cyclophosphamide Chemotherapy: Initial Results From a Phase I Clinical Trial Treating CLL Patients with Autologous CD19-Targeted T Cells
    Brentjens, Renier J.
    Hollyman, Daniel
    Park, Jae
    Santos, Elmer
    Yeh, Raymond
    Stefanski, Jolanta
    Taylor, Clare
    Weiss, Mark A.
    Filippa, Daniel
    Riviere, Isabelle
    Sadelain, Michel W.
    BLOOD, 2009, 114 (22) : 1335 - 1335
  • [2] Safety and tolerability of conditioning chemotherapy followed by CD19-targeted CAR T cells for relapsed/refractory CLL
    Geyer, Mark B.
    Riviere, Isabelle
    Senechal, Brigitte
    Wang, Xiuyan
    Wang, Yongzeng
    Purdon, Terence J.
    Hsu, Meier
    Devlin, Sean M.
    Palomba, M. Lia
    Halton, Elizabeth
    Bernal, Yvette
    van Leeuwen, Dayenne G.
    Sadelain, Michel
    Park, Jae H.
    Brentjens, Renier J.
    JCI INSIGHT, 2019, 4 (09)
  • [3] Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    Brentjens, Renier J.
    Riviere, Isabelle
    Park, Jae H.
    Davila, Marco L.
    Wang, Xiuyan
    Stefanski, Jolanta
    Taylor, Clare
    Yeh, Raymond
    Bartido, Shirley
    Borquez-Ojeda, Oriana
    Olszewska, Malgorzata
    Bernal, Yvette
    Pegram, Hollie
    Przybylowski, Mark
    Hollyman, Daniel
    Usachenko, Yelena
    Pirraglia, Domenick
    Hosey, James
    Santos, Elmer
    Halton, Elizabeth
    Maslak, Peter
    Scheinberg, David
    Jurcic, Joseph
    Heaney, Mark
    Heller, Glenn
    Frattini, Mark
    Sadelain, Michel
    BLOOD, 2011, 118 (18) : 4817 - 4828
  • [4] CD19-Targeted Normal and CLL Patient T Cells Expanded with Beads Can Eradicate Systemic Tumors In Vivo
    Stefanski, J.
    Brentjens, R.
    Hollyman, D.
    Bonyhadi, M.
    Sadelain, M.
    Riviere, I.
    MOLECULAR THERAPY, 2006, 13 : S102 - S102
  • [5] Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure
    Gauthier, Jordan
    Hirayama, Alexandre V.
    Purushe, Janaki
    Hay, Kevin A.
    Lymp, James
    Li, Daniel H.
    Yeung, Cecilia C. S.
    Sheih, Alyssa
    Pender, Barbara S.
    Hawkins, Reed M.
    Vakil, Aesha
    Tinh-Doan Phi
    Steinmetz, Rachel N.
    Shadman, Mazyar
    Riddell, Stanley R.
    Maloney, David G.
    Turtle, Cameron J.
    BLOOD, 2020, 135 (19) : 1650 - 1660
  • [6] Generation of CD19-Targeted Chimeric Antigen Receptor T Cells
    Kiani, Jafar
    Naderi, Mahmood
    Torabi-Rahvar, Monireh
    Ranjbar, Azam
    Aghayan, Hamid-Reza
    Janzamin, Ehsan
    Ahmadbeigi, Naser
    ARCHIVES OF IRANIAN MEDICINE, 2019, 22 (01) : 7 - 10
  • [7] CD19-targeted CAR T cells in refractory antisynthetase syndrome
    Mueller, Fabian
    Boeltz, Sebastian
    Knitza, Johannes
    Aigner, Michael
    Voelkl, Simon
    Kharboutli, Soraya
    Reimann, Hannah
    Taubmann, Jule
    Kretschmann, Sascha
    Roesler, Wolf
    Manger, Bernhard
    Wacker, Jochen
    Mougiakakos, Dimitrios
    Jabari, Samir
    Schroeder, Rolf
    Uder, Michael
    Roemer, Frank
    Kroenke, Gerhard
    Mackensen, Andreas
    Schett, Georg
    LANCET, 2023, 401 (10379): : 815 - 818
  • [8] Retrovirally expressed 4-1BBL dramatically increases proliferation and in vivo persistence of adoptively transferred CD19-targeted T cells, promoting complete tumor elimination.
    Condomines, Maud
    Plotkin, Jason
    Markley, John
    Gunset, Gertrude
    Sadelain, Michel
    JOURNAL OF IMMUNOLOGY, 2010, 184
  • [9] Treatment of a patient with severe systemic sclerosis (SSc) using CD19-targeted CAR T cells
    Bergmann, Christina
    Mueller, Fabian
    Distler, Joerg H. W.
    Gyoerfi, Andrea-Hermina
    Voelkl, Simon
    Aigner, Michael
    Kretschmann, Sascha
    Reimann, Hannah
    Harrer, Thomas
    Bayerl, Nadine
    Boeltz, Sebastian
    Wirsching, Andreas
    Taubmann, Jule
    Roesler, Wolf
    Spriewald, Bernd
    Wacker, Jochen
    Atzinger, Armin
    Uder, Michael
    Kuwert, Torsten
    Mackensen, Andreas
    Schett, Georg
    ANNALS OF THE RHEUMATIC DISEASES, 2023, 82 (08) : 1117 - 1120
  • [10] CD19-Targeted T Cells for Hematologic Malignancies Clinical Experience to Date
    Davila, Marco L.
    Sauter, Craig
    Brentjens, Renier
    CANCER JOURNAL, 2015, 21 (06): : 470 - 474
12345