A convenient approach towards 2-and 3-aminobenzo[b]thiophenes

被引：24

作者：

Androsov, Dmitry A. ^{[1
,2
]}

Solovyev, Andrey Y. ^{[2
]}

Petrov, Mikhail L. ^{[1
]}

Butcher, Ray J. ^{[3
]}

Jasinski, Jerry P. ^{[4
]}

机构：

[1] Str Petersburg State Inst Technol, Dept Organ Chem, St Petersburg 190013, Russia

[2] Bowling Green State Univ, Ctr Photochem Sci, Bowling Green, OH 43403 USA

[3] Howard Univ, Dept Chem, Washington, DC 20059 USA

[4] Keene State Coll, Dept Chem, Keene, NH 03435 USA

来源：

TETRAHEDRON | 2010年 / 66卷 / 13期

关键词：

PALLADIUM-CATALYZED AMINATION; WILLGERODT-KINDLER REACTION; ESTROGEN-RECEPTOR MODULATORS; ONE-POT SYNTHESIS; SECONDARY-AMINES; 1,2,3-THIADIAZOLES; EFFICIENT; DERIVATIVES; MECHANISM; BASE;

D O I：

10.1016/j.tet.2010.01.069

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 1-(2-chloro-5-nitrophenyl)ethanone via Willgerodt-Kindler route with primary or secondary amines and Sulfur allows a simple, efficient one-pot synthesis of 3-aminobenzo[b]thiophenes. Base-catalyzed transformation of 4-(2-chloro-5-nitrophenyl)-1,2,3-thiadiazole in the presence of primary and secondary amines offers a convenient approach towards 2-aminobenzo[b]thiophenes. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2474 / 2485

页数：12

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