Microtubule-severing enzymes

被引：209
|
作者：
Roll-Mecak, Antonina [1 ]
Mcnally, Francis J. [2 ]
机构：
[1] NINDS, Cell Biol & Biophys Unit, Porter Neurosci Res Ctr, Bethesda, MD 20892 USA
[2] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 01期
关键词：
SPASTIC PARAPLEGIA PROTEIN; ESCRT-III RECOGNITION; CAENORHABDITIS-ELEGANS; STRUCTURAL BASIS; MEIOTIC SPINDLE; AAA-ATPASE; DYNAMIC INSTABILITY; GAMMA-TUBULIN; E3; LIGASE; KATANIN;
D O I：
10.1016/j.ceb.2009.11.001
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In 1993, an enzyme with an ATP-dependent microtubule-severing activity was purified from sea urchin eggs and named katanin, after the Japanese word for sword. Now we know that katanin, spastin, and fidgetin form a family of closely related microtubule-severing enzymes that is widely distributed in eukaryotes ranging from Tetrahymena and Chlamydomonas to humans. Here we review the diverse in vivo functions of these proteins and the recent significant advances in deciphering the biophysical mechanism of microtubule severing.
引用
收藏
页码：96 / 103
页数：8
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