Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells under Hypoxia via mir-491

被引：34
|
作者：
Chen, Yingying [1 ]
Zhang, Yuqiang [1 ]
Song, Wei [2 ]
Zhang, Ying [1 ]
Dong, Xiu [3 ]
Tan, Mingqi [1 ]
机构：
[1] China Med Univ, Shengjing Hosp, Resp Med Dept, Shenyang 110042, Liaoning, Peoples R China
[2] China Med Univ, Shengjing Hosp, Oncol Med Dept, Shenyang 110042, Liaoning, Peoples R China
[3] Liaoning Univ Tradit Chinese Med, Sch Preclin Med, 79 Chong Shan Dong Lu, Shenyang 110847, Liaoning, Peoples R China
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2019年 / 19卷 / 13期
关键词：
Ginsenoside Rh2; hypoxia; lung adenocarcinoma; migration; mir-491; antitumor activity; MICRORNA EXPRESSION PROFILE; MATRIX METALLOPROTEINASES; INVASION; MMP-9; PROLIFERATION; HIF-1-ALPHA; METASTASIS; THERAPY;
D O I：
10.2174/1871520619666190704165205
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Ginsenoside Rh2 (Rh2), which is extracted from ginseng, exerts antitumor activity. Here we would like to study the role of Rh2 on hypoxia-induced migration in lung adenocarcinoma. Methods: Lung adenocarcinoma A549 and H1299 cells were cultured in 1% O-2 condition to mimic the hypoxic tumor micmenvironment. The migrations of cancer cells were measured by transwell assay and scratch assay. Results: Rh2 could inhibit hypoxia-induced A549 and H1299 cell migration via increase of mir-491 expression. Further, mir-491 antisense oligonucleotide could repress hypoxia-induced migration and the expression of matrix metalloproteinase (MMP)-9 expression in Rh2-treated A549 cells. Conclusion: These findings suggest that Rh2 exerts anti-metastasis activity in the hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.
引用
收藏
页码：1633 / 1641
页数：9
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