The JAK2/STAT3 inhibitor cucurbitacin I (JS']JSI-124) has potent anti-myeloma effects independent of STAT3 inhibition

被引：0
|
作者：
Ma, H. H. [1 ]
Ziegler, J. [1 ]
Lentzsch, S. [1 ]
Mapara, M. Y. [1 ]
机构：
[1] Univ Pittsburgh, Pittsburgh Canc Inst, Hillman Canc Ctr, Div Hematol Oncol, Pittsburgh, PA USA
来源：
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL | 2007年 / 92卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：143 / 143
页数：1
相关论文
共 50 条
  • [1] Cucurbitacin I (JS']JSI-124) has potent anti-myeloma effects independent of its inhibition of JAK2-induced STAT3 activation
    Ma, Huihui
    Ziegler, Judith
    Feng, Ren-Tien
    Lentzsch, Suzanne
    Mapara, Markus
    BLOOD, 2007, 110 (11) : 743A - 743A
  • [2] JS']JSI-124 may induces apoptosis of leukaemia cells independent of JAK2/STAT3 pathway and compromise immune response
    Masengere, H.
    Miao, M.
    Luan, Z.
    Yu, G.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1867 - 1867
  • [3] JS']JSI-124 (Cucurbitacin I) Inhibits Tumor Angiogenesis of Human Breast Cancer Through Reduction of STAT3 Phosphorylation
    Qi, Jia
    Xia, Ge
    Huang, Cheng Rong
    Wang, Jian Xia
    Zhang, Jian
    AMERICAN JOURNAL OF CHINESE MEDICINE, 2015, 43 (02): : 337 - 347
  • [4] Activation of the NF-κB Pathway by the STAT3 Inhibitor JS']JSI-124 in Human Glioblastoma Cells
    McFarland, Braden C.
    Gray, G. Kenneth
    Nozell, Susan E.
    Hong, Suk W.
    Benveniste, Etty N.
    MOLECULAR CANCER RESEARCH, 2013, 11 (05) : 494 - 505
  • [5] Cucurbitacin I (JS']JSI-124)-dependent inhibition of STAT3 permanently suppresses the pro-carcinogenic effects of active breast cancer-associated fibroblasts
    Al-Harbi, Bothaina
    Aboussekhra, Abdelilah
    MOLECULAR CARCINOGENESIS, 2021, 60 (04) : 242 - 251
  • [6] Inhibition of Constitutive Activation of STAT3 by Curcurbitacin-I (JS']JSI-124) Sensitized Human B-Leukemia Cells to Apoptosis
    Ishdorj, Ganchimeg
    Johnston, James B.
    Gibson, Spencer B.
    MOLECULAR CANCER THERAPEUTICS, 2010, 9 (12) : 3302 - 3314
  • [7] Cucurbitacin-I (JS']JSI-124) induces apoptosis in chronic lymphocytic leukemia (CLL) cells through inhibiting STAT3 activation and XIAP expression
    Ishdorj, Ganchimeg
    CANCER RESEARCH, 2010, 70
  • [8] Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JS']JSI-124
    Molavi, Ommoleila
    Ma, Zengshuan
    Hamdy, Samar
    Lavasanifar, Afsaneh
    Samuel, John
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2009, 31 (02) : 214 - 221
  • [9] Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JS']JSI-124 in a mouse melanoma tumor model
    Molavi, Ommoleila
    Ma, Zengshuan
    Hamdy, Samar
    Lai, Raymond
    Lavasanifar, Afsaneh
    Samuel, John
    IMMUNOLOGY AND CELL BIOLOGY, 2008, 86 (06): : 506 - 514
  • [10] The JAK2/STAT3 pathway is involved in the anti-melanoma effects of atractylenolide I
    Fu, Xiu-Qiong
    Chou, Ji-Yao
    Li, Ting
    Zhu, Pei-Li
    Li, Jun-Kui
    Yin, Cheng-Le
    Su, Tao
    Guo, Hui
    Lee, Kin-Wah
    Hossen, Muhammad Jahangir
    Chou, Gui-Xin
    Yu, Zhi-Ling
    EXPERIMENTAL DERMATOLOGY, 2018, 27 (02) : 201 - 204
12345